"When I came out of my mom's womb, I had 'sitcom' stamped on my forehead."

"Being an actor, the less people know about my personal life, the more open-minded they can be about each role I play".

"When you see me play Jack, I want you to believe that that's a gay character. After "Will & Grace" (1998) is over, when I play a straight character, I want you to believe that, too." - Etcetera interview

"If you see a movie and I'm in it, and the first thing you think of is who I'm sleeping with, then you're not watching the performance; you're watching the personality."